Gambling & Gaming Disorders

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Gambling — whether it be the lottery, scratch cards, casino games, bingo, slot machines, Internet poker, or sports betting — is more acceptable and accessible than ever before. For most people, gambling is a recreational activity. But for a significant minority, it progresses to a serious problem.

“In a process addiction you’re not going to get a physical withdraw. But the same parts of the brain are stimulated, the mid-brain, where dopamine is released. The dopamine reward centers are lit up by gambling or other kinds of process addiction in a way that a substance would light them up. So someone with a low dopamine level as a baseline might need to go out and gamble, high risk gambling, just to bring your dopamine levels up to what a normal person’s dopamine level would be just walking down the street. And then if they are unable to gamble, let’s say, you have a crash, which is not unlike a crash from cocaine where the dopamine is over used, depleted, and you crash down but then begin to crave that dopamine release again, which brings people back to the gambling.” – Dr. Bruce Singer

Recently, scientists and mental health professionals decided to classify problem gambling as a behavioral addiction, the first of its kind, putting it in a category of disorders that also includes substance abuse. The reason for this change comes from neuroscience research, which has shown that gambling addicts have a lot in common with drug and alcohol addicts, including changes in behavior and brain activity.

A Behavioral Addiction

Gambling disorder refers to the uncontrollable urge to gamble, despite serious personal consequences. This can impact a person’s interpersonal relationships, financial situation, and physical and mental health. Yet it has only recently been recognized as an addiction.

Problem gambling was first classified as a psychiatric disorder in 1980. In the third edition of the Diagnostic and Statistical Manual, the American Psychiatric Association’s guide to psychiatric disorders, the condition was termed “pathological gambling” and classified as an impulse control disorder, alongside disorders like kleptomania and pyromania. In 2013, it was renamed “gambling disorder” and moved to the Substance-Related and Addictive Disorders category, which includes alcohol and drug addictions.

The decision to move this disorder alongside substance use disorders reflects a new understanding of the underlying commonalities between gambling and other addictions. There is a growing body of neuroscience and psychology research suggesting problem gambling is similar to drug addiction.

Many of the diagnostic criteria for this disorder share features with those for drug dependence, such as tolerance, withdrawal, repeated unsuccessful attempts to cut back or quit, and major interference in one’s life. Problem gamblers also report cravings and highs in response to gambling.

“People will get inured to the high of gambling at a certain point and need to gamble with bigger bets and riskier betting options,” says Jon Grant, who studies addiction at the University of Chicago. “When people try to stop, they go through withdrawal, with insomnia, agitation, irritability, and a feeling of being ill at ease, similar to what we see in some substance abuse disorders.”

Problem gambling also runs in families, alongside other addictions. “If you have family members with alcohol use disorders, you’re at increased risk for gambling disorder,” says Nancy Petry, who studies addictive disorders at the University of Connecticut and served on the committee that led the reclassification of problem gambling as a behavioral addiction.

There may be some common genetic or brain differences in people who are more inclined to develop addictions, Petry says. For example, research shows that problem gamblers and drug addicts share many of the same genetic predispositions for impulsivity and reward-seeking behaviors.

This Is Your Brain on Gambling

Much of the research that supports this disorder with other addictions comes from brain imaging studies and neurochemical tests. These have revealed commonalities in the way that gambling and drugs of abuse act on the brain, and the way the brains of addicts respond to such cues. The evidence indicates that it activates the brain’s reward system in much the same way that a drug does.

“Across many studies, the same brain areas come up time and time again — the ventral striatum and the prefrontal cortex,” says Luke Clark, a psychologist at the University of British Columbia.

The ventral striatum, located deep inside the brain, has been termed the brain’s reward center, and it’s been implicated in reward processing as well as substance abuse.

When people with gambling disorder watch gambling videos or participate in simulated gambling while their brains are being scanned, scientists can see changes in blood flow in specific brain areas, indicating which areas are more active. In one study, both problem gamblers and cocaine addicts watched videos related to their addictions while in a functional magnetic resonance imaging (fMRI)scanner. Both groups showed diminished activation in the ventral striatum compared to healthy control participants. Problem gamblers also showed less ventral striatum activity during simulated gambling games and during the anticipation of monetary rewards than did people without gambling problems.

“These results resonate with findings showing that adolescent smokers and individuals with alcohol dependence also show blunted ventral striatum activation during reward anticipation,” says Marc Potenza, a psychiatrist who studies gambling addiction at the Yale School of Medicine.

While the finding that problem gamblers have lower activation in reward pathways may seem counterintuitive, some scientists think it can be explained by what’s known as the reward deficiency model. They argue that people prone to addiction have an underactive brain reward system and that such people are drawn to ways to stimulate their reward pathways.

The other brain region that is often implicated in gambling and substance use disorders is the prefrontal cortex. This region is involved in decision-making, controlling impulsivity, and cognitive control. Several studies have shown that problem gamblers and drug addicts both showed less activation of the prefrontal cortex in response to gambling-related cues.

“Given the role of the prefrontal cortex in reward evaluation and delayed discounting, where people make decisions about choosing an immediate small reward versus a later, larger reward, the findings seem to suggest that individuals with gambling problems may have differences in functioning in this brain region,” Potenza says.

Many studies have shown that people with this disorder are more impulsive than other people. They may have difficulty controlling their impulses due to reduced activation of the prefrontal cortex.

“I think the take-home message is that there are probably several types of processing problems in people with gambling disorder,” Grant says. “Research indicates they are processing risk and reward incorrectly and processing current versus long-term consequences incorrectly.”

Learn more about Gambling Addiction and Problem Gambling

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