Cocaine is addictive due to its effect on the reward pathway in the brain. After a short period of use, there is a high risk that dependence will occur. Its use also increases the risk of strokemyocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.Cocaine sold on the street is commonly mixed with local anesthetics, cornstarch, quinine, or sugar, which can result in additional toxicity. Following repeated doses a person may have decreased ability to feel pleasure and be very physically tired.

Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine.This results in greater concentrations of these three neurotransmitters in the brain. It can easily cross the blood–brain barrier and may lead to the breakdown of the barrier.Cocaine is a naturally occurring substance found in the cocaplant which is mostly grown in South America. In 2013, 419 kilograms were produced legally.It is estimated that the illegal market for cocaine is 100 to US$500 billion each year.With further processing crack cocaine can be produced from cocaine

Cocaine is the second most frequently used illegal drug globally, after cannabis.Between 14 and 21 million people use the drug each year. Use is highest in North America followed by Europe and South America.Between one and three percent of people in the developed world have used cocaine at some point in their life.In 2013, cocaine use directly resulted in 4,300 deaths, up from 2,400 in 1990.The leaves of the coca plant have been used by Peruvians since ancient times.Cocaine was first isolated from the leaves in 1860.Since 1961, the international Single Convention on Narcotic Drugs has required countries to make recreational use of cocaine a crime.

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